Saint Macarius the Great was from the Thebaid of Egypt, a disciple, as some say, of Saint Anthony the Great. He was born about 331 and struggled in asceticism in the desert at Scete. Although young, he was called "the child elder" because of his great wisdom and austere manner of life. He was ordained presbyter and reposed in 391, at the age of sixty. There are fifty homilies ascribed to him.

It is said of Saint Macarius that he became as a God upon earth, for even as God protects the whole world, so did he cover the faults he saw as if he did not see them. Once he came back to his cell to find a thief taking his things and loading them on a camel. Macarius' non-possessiveness was so great that he helped the thief load the camel. When the camel refused to rise, Macarius returned to his cell and brought a small hoe, said that the camel wanted the hoe also, loaded it on, and kicked the camel telling it to get up. The camel obeyed Macarius' command, but soon lay down again, and would not move until everything had been returned to Macarius. His contemporary, Saint Macarius of Alexandria, was so called because he came from Alexandria and was therefore of that Greek-speaking colony; while Saint Macarius the Great is also called "of Egypt," that is, he belonged to the ancient race native to Egypt, the Copts.

The great teacher and invincible defender of the One, Holy, Catholic, and Apostolic Church, Saint Mark, was the offspring and scion of the imperial city, Constantinople. Reared by most pious parents, and instructed in secular and spiritual wisdom, he became preeminent in both. Saint Mark lived as an ascetic on the Prince's Islands and later in the monastery of Saint George Magana in Constantinople. He passed through all the degrees of the priesthood, and was finally advanced to the dignity of Archbishop and the lofty throne of the Metropolis of Ephesus. At the insistence of Emperor John Paleologos, the Saint was sent to the council of the Latins in Florence, to unite the churches that had been divided for so many years. He astounded the papal teachers with the divine wisdom of his words, and was the only one who did not sign the blasphemous decree of that false council. Because of this, the Holy Church of Christ has ever honored this great man as a benefactor, teacher, sole defender, and invincible champion of the Apostolic Confession. He reposed in 1443.