When the Emperor Diocletian was at Aquileia, he learned that these Saints were Christians, and had them brought before him. Because they would not deny Christ, he had them imprisoned, and when he went into Macedonia, he committed them to Dulcitius the Prefect, who, however, lost his understanding and became incapable of doing them any harm. Diocletian then gave Count Sisinius charge over them. He had Saints Agape and Chionia burned; he ordered that Saint Irene be put in a brothel, but by the providence of God this was not accomplished, and she was shot with an arrow. These holy sisters suffered martyrdom in Thessalonica in the year 295.

This Martyr was Bishop of the royal cities Seleucia and Ctesiphon in Persia. As the number of Christians increased in Persia, building churches and appointing clergy, the Magi, guardians of the Persian religion, and the Jews, who also envied them, accused Symeon to Sapor II, King of Persia, saying that Symeon was a friend of the Roman Emperor and his spy. Then began Sapor's persecution of the Christians of Persia, about the year 343. The Magi together with the Jews destroyed the churches. Saint Symeon was brought before Sapor, and, refusing to worship the sun, was imprisoned. On Holy and Great Friday of that year, Saint Symeon was brought out of prison with a hundred others, bishops, priests, and deacons. As each was taken to be slain, Saint Symeon exhorted him to be of good courage; he was slain last of all. It is said that 1,150 Martyrs were slain; an innumerable multitude of Christians were slain throughout Persia during this persecution, among them Saints Acepsimas, Joseph, and Aethalas (see Nov. 3).