Saint Blaise was Bishop of Sebastia. Divine grace, through which he healed the diseases of men and beasts, and especially of infants, made his name famous. He contested for the Faith under Licinius in the year 316. Saint Blaise is invoked for the healing of throat ailments.

As for the renowned Empress Theodora, she was from Paphlagonia and was the daughter of a certain Marinus, the commander of a military regiment. While being the wife of the Emperor Theophilus, the last of the Iconoclasts, she adorned the royal diadem with her virtue and piety; as long as her husband Theophilus lived, she privately venerated icons, despite his displeasure. After his death, she restored the holy icons to public veneration; this is commemorated on the Sunday of Orthodoxy, the First Sunday of the Great Fast. She governed the Empire wisely for fifteen years, since her son Michael was not yet of age. But in 857 she forsook her royal power and entered a certain convent in Constantinople called Gastria, where she finished the course of her life in holiness and reposed in the Lord. Her sacred incorrupt remains are found in Corfu, in the Church of the Most Holy Theotokos of the Cave, in the capital city of the island (see also Dec. 12).

This holy Father, who was from Melitene of Armenia, was a blameless man, just, reverent, sincere, and most gentle. Consecrated Bishop of Sebastia in 357, he was later banished from his throne and departed for Beroea of Syria (this is the present-day Aleppo). After the Arian bishop of Antioch had been deposed, the Orthodox and the Arians each strove to have a man of like mind with themselves become the next Bishop of Antioch. Meletius was highly esteemed by all, and since the Arians believed him to share their own opinion, they had him raised to the throne of Antioch. As soon as he had taken the helm of the Church of Antioch, however, he began preaching the Son's consubstantiality with the Father. At this, the archdeacon, an Arian, put his hand over the bishop's mouth; Meletius then extended three fingers towards the people, closed them, and extended one only, showing by signs the equality and unity of the Trinity. The embarrassed archdeacon then seized his hand, but released his mouth, and Meletius spoke out even more forcibly in defense of the Council of Nicaea. Shortly after, he was banished by the Arian Emperor Constantius, son of Saint Constantine the Great. After the passage of time, he was recalled to his throne, but was banished again the third time by Valens. It was Saint Meletius who ordained Saint John Chrysostom reader and deacon in Antioch (see Nov. 13). He lived until the Second Ecumenical Council in 381 (which was convoked against Macedonius, Patriarch of Constantinople, the enemy of the Holy Spirit), over which he presided, being held in great honor as a zealot of the Faith and a venerable elder hierarch.

Some time before, when the Emperor Gratian had made the Spanish General Theodosius commander-in-chief of his armies in the war against the barbarians, Theodosius had a dream in which he saw Meletius, whom he had never met, putting upon him the imperial robe and crown. Because of Theodosius's victories, Gratian made him Emperor of the East in Valens' stead in 379. When, as Emperor, Saint Theodosius the Great convoked the Second Ecumenical Council in Constantinople two years later, he forbade that anyone should tell him who Meletius was; and as soon as he saw him, he recognized him, ran to him with joy, embraced him before all the other bishops, and told him of his dream.

While at the Council, Saint Meletius fell ill and reposed a short while after. Saint Gregory of Nyssa, among others, gave a moving oration at his funeral; bewailing the loss of him whom all loved as a father, he said, "Where is that sweet serenity of his eyes? Where that bright smile upon his lips? Where that kind right hand, with fingers outstretched to accompany the benediction of the mouth?" (PG 46:8-6). And he lamented, "Our Elias has been caught up, and no Elisseus is left behind in his place." (ibid., 860). The holy relics of Saint Meletius were returned to Antioch and were buried beside Saint Babylas the Martyr (see Sept. 4), in the Church dedicated to the Martyr which Meletius, in his zeal for the Martyr's glory, had helped build with his own hands.

Saint Martinian, who was from Caesarea of Palestine, flourished about the beginning of the fifth century. He struggled in the wilderness from his youth. After he had passed twenty-five years in asceticism, the devil brought a temptation upon him through a harlot, who when she heard the Saint praised for his virtue, determined to try his virtue, or rather, to undo it. Coming to his cell by night as it rained, and saying she had lost her way, she begged with pitiful cries to be admitted in for the night, lest she fall prey to wild beasts. Moved with compassion, and not wishing to be guilty of her death should anything befall her, he allowed her to enter. When she began to seduce him, and the fire of desire began to burn in his heart, he kindled a fire and stepped into it, burning his body, but saving his soul from the fire of Gehenna. And she, brought to her senses by this, repented, and, following his counsel, went to Bethlehem to a certain virgin named Paula, with whom she lived in fasting and prayer; before her death, she was deemed worthy of the gift of wonder-working. Saint Martinian, when he recovered from the burning, resolved to go to some more solitary place, and took a ship to a certain island, where he struggled in solitude for a number of years. Then a young maiden who had suffered a shipwreck came ashore on his island. Not wishing to fall into temptation again, he departed, and passed his remaining time as a wanderer, coming to the end of his life in Athens.

This Saint, who was from the East, lived during the reign of Saint Theodosius the Younger. In 442 he enlisted in the Fourth Military Company of the Scholarii, that is, the Imperial Guard. Afterwards, he became a monk on a certain mountain in Bithynia (which later took his name), not far from Chalcedon. On becoming the archimandrite of the monastics gathered there, and proving himself to be most enduring in asceticism and most Orthodox in his faith, he reposed during the reign of the Emperor Leo the Great of Thrace, who reigned from 457 to 474.

This Apostle, who was from Colossae, was a bond-servant of that Philemon to whom the Apostle Paul addressed his epistle. Onesimus escaped from Philemon and fled to Rome, where he became a disciple of Saint Paul. Saint Paul brought him to the Faith of Christ, and then sent him back to his master, who in turn gave him his freedom and sent him back to Rome again, where he ministered to Saint Paul. Later, he was seized because he was a Christian and was sent to Puteoli, where he was beaten to death with clubs. Saint Onesimus is also commemorated on November 22 with the holy Apostles Philemon, Apphia, and Archippus.

This Martyr contested during the reign of Maximian, in the year 290, in Caesarea of Palestine, and was put to death by command of Firmilian, the Governor of Palestine. His fellow contestants' names are Valens, Paul, Seleucus, Porphyrius, Julian, Theodulus, and five others from Egypt: Elias, Jeremias, Esaias, Samuel, and Daniel. Their martyrdom is recorded in Book VIII, ch. 11 of Eusebius's Ecclesiastical History, called The Martyrs of Palestine.

Saint Theodore who was from Amasia of Pontus, contested during the reign of Maximian (286-305). He was called Tyro, from the Latin Tiro, because he was a newly enlisted recruit. When it was reported that he was a Christian, he boldly confessed Christ; the ruler, hoping that he would repent, gave him time to consider the matter more completely and then give answer. Theodore gave answer by setting fire to the temple of Cybele, the "mother of the gods," and for this he suffered a martyr's death by fire. See also the First Saturday of the Fast.