This common feast of these three teachers was instituted a little before the year 1100, during the reign of the Emperor Alexis I Comnenus, because of a dispute and strife that arose among the notable and virtuous men of that time. Some of them preferred Basil, while others preferred Gregory, and yet others preferred John Chrysostom, quarreling among themselves over which of the three was the greatest. Furthermore, each party, in order to distinguish itself from the others, assumed the name of its preferred Saint; hence, they called themselves Basilians, Gregorians, or Johannites. Desiring to bring an end to the contention, the three Saints appeared together to the saintly John Mavropous, a monk who had been ordained Bishop of Euchaita, a city of Asia Minor, they revealed to him that the glory they have at the throne of God is equal, and told him to compose a common service for the three of them, which he did with great skill and beauty. Saint John of Euchaita (celebrated Oct. 5) is also the composer of the Canon to the Guardian Angel, the Protector of a Man's Life. In his old age, he retired from his episcopal see and again took up the monastic life in a monastery in Constantinople. He reposed during the reign of the aforementioned Emperor Alexis Comnenus (1081-1118).

These Saints lived during the years of Diocletian. Saint Cyrus was from Alexandria, and Saint John was from Edessa of Mesopotamia. Because of the persecution of that time, Cyrus fled to the Gulf of Arabia, where there was a small community of monks. John, who was a soldier, heard of Cyrus' fame and came to join him. Henceforth, they passed their life working every virtue, and healing every illness and disease freely by the grace of Christ; hence their title of "Unmercenaries." They heard that a certain woman, named Athanasia, had been apprehended together with her three daughters, Theodora, Theoctiste, and Eudoxia, and taken to the tribunal for their confession of the Faith. Fearing lest the tender young maidens be terrified by the torments and renounce Christ, they went to strengthen them in their contest in martyrdom; therefore they too were seized. After Cyrus and John and those sacred women had been greatly tormented, all were beheaded in the year 292. Their tomb became a renowned shrine in Egypt, and a place of universal pilgrimage. It was found in the area of the modern day resort near Alexandria named Abu Kyr.