These Saints were from the city of Edessa in Mesopotamia and flourished during the reign of Justin the Younger (565-578). After a pilgrimage to Jerusalem they were moved with a desire to forsake the world; they were tonsured monks by the Abbot Nicon, and soon after left the monastery to struggle together in the wilderness near the Dead Sea. When they had passed a little more than thirty years together in silence and prayer, Symeon, having reached the heights of dispassion, departed for Emesa in Syria, where he passed the rest of his life playing the fool, saving many souls from sin while hiding his sanctity with seemingly senseless behavior. He reposed in 570; by the providence of God, John, who had remained in the wilderness, departed soon after.

Saint Markella was born in the 14^th century on the island of Chios and was the daughter of the mayor of her town. She was raised in the Christian faith by pious parents, but lost her mother at a young age. This was especially difficult for her father who fell into depression. The young Markella was devoted to Christ and strove to preserve her virginity, fighting off numerous temptations from the Devil. Seeing he could make no progress with Markella, the Evil One turned his attention to her father, and enflamed within him an unnatural lust for his daughter.

One day he declared his desire for her at which she ran away in tears and fear. Arriving at the edge of the water and with nowhere to run, a rock opened up for Markella to enter so that her lower half could be enclosed within the rock. When her father arrived in pursuit of her, he was furious to have been deprived of his desire and beheaded his daughter there. The miraculous rock remains on Chios in the church dedicated to Saint Markella the Virgin-Martyr and is said to spring healing waters.

According to tradition, Anna, the ancestor of God, lived for sixty-nine years, and her spouse Joachim, for eighty; according to one account, Saint Joachim died two years before Saint Anna. The Theotokos had been orphaned of both her parents already when she was eleven years of age, when she was living in the Temple (see Sept. 8 and Nov. 21). Saint Anna is invoked for conceiving children, and for help in difficult childbirth.

Saint Paraskeve, who was from a certain village near Rome, was born to pious parents, Agatho and Politia. Since she was born on a Friday (in Greek, Paraskeve), she was given this name, which means "preparation" or "preparedness" (compare Matt. 27:62, Mark 15:42, Luke 23:54, and John 19:31, where 'Friday' is called "the day of the preparation"). From childhood she was instructed in the sacred letters and devoted herself to the study of the divine Scriptures, while leading a monastic life and guiding many to the Faith of Christ. During the reign of the Emperor Antoninus Pius, she was apprehended because she was a Christian and was urged to worship the idols, but she answered with the words of Jeremias: "Let the gods that have not made heaven and the earth perish from off the earth" (Jer. 10:11). Because of this she endured exceedingly painful torments, and was beheaded in the year 140. The faithful pray to her for the healing of eye ailments.

This Saint, who had Nicomedia as his homeland, was the son of Eustorgius and Eubula. His father was an idolater, but his mother was a Christian from her ancestors. It was through her that he was instructed in piety, and still later, he was catechized in the Faith of Christ by Saint Hermolaus (see July 26) and baptized by him. Being proficient in the physician's vocation, he practiced it in a philanthropic manner, healing every illness more by the grace of Christ than by medicines. Thus, although his parents had named him Pantoleon ("in all things a lion"), because of the compassion he showed for the souls and bodies of all, he was worthily renamed Panteleimon, meaning "all-merciful." On one occasion, when he restored the sight of a certain blind man by calling on the Divine Name, he enlightened also the eyes of this man's soul to the knowledge of the truth. This also became the cause for the martyrdom of him who had been blind, since when he was asked by whom and in what manner his eyes had been opened, in imitation of that blind man of the Gospel he confessed with boldness both who the physician was and the manner of his healing. For this he was put to death immediately. Panteleimon was arrested also, and having endured many wounds, he was finally beheaded in the year 305, during the reign of Maximian. Saint Panteleimon is one of the Holy Unmercenaries, and is held in special honor among them, even as Saint George is among the Martyrs.